Many (maybe even most) infographics focus primarily on a cute visual concept and forget about the data they need to communicate. The result: pretty pictures that are impossible to understand.
First, focus on the data and think what you want to show: a trend, a comparison, a ranking, a contrast. That should be the basis for the design of your graphic.
Then, remember that cute icons can be as hard to understand as a bullet point: sometimes it can be more effective to write down the words “home” and “work” than trying to come up with illustrations of a house and an office.
Clients often request a cool infographic to get their message across. My response is to stuck to a more traditional presentation format, but if they insist on an infographic look, to go more creative on colors, shapes, and especially fonts at the expense of technical compatibility and the ability of everyone in your organisation to edit the slides for their own needs.
The WTF Visualizations blog is full of bad infographics, enjoy! (Via Daria)